fnctId=profl,fnctNo=46
관리
이대희
- 소속
- 생명과학대학 해양바이오식품학과
- 전화번호
- 033-640-2347
- 이메일
- neogene@gwnu.ac.kr
- 연구분야
- 해양천연물 기능성 식의약품소재 연구
세부내용
학력
- 고려대학교 식품공학과 학사
- 고려대학교 생명공학원 식품생물학 석사
- 고려대학교 생명공학원 식품생명공학 박사
경력
- 2019.9 ~ 현재 강릉원주대 생명과학대학 해양식품공학과 교수
- 2015.2 ~ 2019.8 고려대학교 의과대학 의과학대학원 연구교수
- 2014.2 ~ 2015.1 University of Pittsburgh Hillman Cancer Center 연구교수
- 2010.4 ~ 2014.1 University of Virginia 신경외과 (뇌종양 항암제개발) 책임연구원
- 2006.8 ~ 2010.3 University of Pittsburgh Hillman Cancer Center 책임연구원
- 2005.3 ~ 2006.7 경희대학교 한의과대학 본초학 연구실 박사 후 연구원
전문연구분야
- 1. In vivo 마우스 시스템을 이용한 항암제 개발 연구
- 2. 해양생물 유래 의약품 소재 개발에 관한 연구
- 3. 항염, 항산화, 항알러지(아토피 및 여드름), 항암 및 퇴행성뇌질환 연구
- 4. In vivo 모델 적용을 통한 천연물 소재의 기능성 검증 및 생물학적 유용성(bioavailability) 연구
주요논문
- 1. Lee, D. H., Jun, W. J., Shin, D. H., Cho, H. Y., and Hong, B. S.Effect of Culture Conditions on Production of 5-Aminolevulinic Acid by Recombinant Escherichia coli. Bioscience, Biotechnology, and Biochemistry. 69(3): 470-476. (2005)
- 2. Lee, D. H., Jun, W. J., Yoon, J. W., Cho, H. Y., and Hong, B. S.Process Strategies to Enhance the Production of 5-Aminolevulinic Acid with Recombinant E.coli.J. Microbiol. Biotechnol. 14(6): 1310-1317. (2004)
- 3. Jun, W. J., Kim, S. H., Lee, D. H., Jung, J. W., Shim, S. I., Lee, K. W., Cho, H. Y., and Hong, B. S.In Vitro and In Vivo Effects of Gelidium amansii on Intestinal Immune System. Food Science and Biotechnology.14(1): 147-151. (2005)
- 4.Lee, D. H., Jun, W. J., Kim, K. M., Shin, D. H., Cho, H. Y., and Hong, B. S. Inhibition of 5-aminolevulenic acid dehydratase in recombinant Escherichia coli using D-glucose. Enzyme and Microbial Technology 32: 27-34. (2003)
- 5. Lee, D. H, Ha, N., Bu, Y.M., Choi, H.I., Park, Y.G.,Kim, Y.B., Kim, M.Y., and Kim, H. Neuroprotective effect of Buddleja officinalis extracton transient middle cerebral artery occlusion in rats.Biol. Pharm. Bull. 29(8): 1608-1612. (2006)
- 6.Bu, Y. M.,Lee, D. H, Kim, M.Y.,Oh, S., Hwang, M.,Chung, J.,Jin, Z., and Kim, H. Neuroprotective effect of Neubo153 on Transient Focal Cerebral Ischemia in Rats. The Korea Journal of Herbology, 21(2): 151-158. (2006)
- 7.Bu, Y., Rho, S., Kim, J., Kim, M.Y., Lee, D.H., Kim, S.Y., Choi, H., and Kim, H.Neuroprotective effect of tyrosol on transient focalcerebral ischemia in rats. Neuroscience letter. 414(3):218-21.) (2007)
- 8. Chung, H., Lee, D.H., Kim, E., Seo, S., Ju, S., Lee, D., Kim, H., andPark, S.Ghrelin Inhibits Apoptosis in Hypothalamic NeuronalCells during Oxygen-Glucose Deprivation. Endocrinology 148(1):148–159. (2007)
- 9. Kim, Y. H.,Lee, D. H.,Jeong, J. H.,Zong Sheng Guo, and Lee,Y. J. Quercetin augments TRAIL-induced apoptotic death: involvement of the ERK signal transduction pathway. Biochemical Pharmacology, 75(10):1946-1958. (2008)– IF 5.091
- 10. Lee, D. H.,Kim, Clifford., Zhang, Lin., and Lee,Y. J. Role of p53, PUMA, and Bax in wogonin-induced apoptosis in human cancer cells. Biochemical Pharmacology, 75(10):2020-2033. (2008)– IF 5.091
- 11. Lee, D. H.,Miroslaw Szczepanski,and Lee,Y. J. Role of Bax in quercetin-induced apoptosis in human cancer cells. Biochemical Pharmacology,15;75(12):2345-55. (2008)– IF 5.091
- 12. Lee, D. H.,and Lee,Y. J. Quercetin suppresses hypoxia-induced accumulation ofhypoxia-inducible factor-1α (HIF-1α)through inhibiting protein synthesis, Journal of Cellular Biochemistry. (May-2008)- Accepted.– IF 3.446
- 13. Lee, D. H., Miroslaw Szczepanski, and Lee, Y. J. Magnolol induces apoptosis via inhibiting the EGFR/PI3K/Akt signaling pathway in human prostate cancer cells. Journal of Cellular Biochemistry. 106(6):1113-1122. (2009). – IF 3.446
- 14.Lee D. H., Juong G. Rhee and Yong J. Lee.Reactive oxygen species upregulate p53 and PUMA; a possible mechanism for apoptosis during combined treatment with TRAIL and wogonin. British Journal ofPharm acology.157(7):1189-202 (2009).
- 15.Soeda A, Park M, Lee D,Mintz A, Androutsellis-Theotokis A, McKay RD, Engh J, Iwama T, Kunisada T, Kassam AB, Pollack IF, Park DM. Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF- 1alpha. Oncogene. 12;28(45):3949-59 (2009) – IF 7.932
- 16.Marco A. Alcala, Jr, Kyungsoo Park, Jinsang Yoo, Dae-Hee Lee, Bae-hang Park, Byeong-Chel Lee, David L. Bartlett, and Yong J. Lee. Effect of hyperthermia in combination with TRAIL on the JNK-Bim signal transduction pathway and growth of xenograft tumors. Journal of Cellular Biochemistry.106(6):1113-1122. (2010).– IF 3.446
- 17.Dae-Hee Lee,Lee Yong J, andKi Han Kwon. Neuroprotective effects of astaxanthin in oxygen-glucose deprivation in SH-SY5Y cells and global cerebral ischemia in rat. Journal of Clinical Biochemistry and Nutrition.47:121-129. (2010). – IF 1.164
- 18.Dae-Hee Lee andCuk-Seong Kim, and Yong J. Lee. Astaxanthin protects against MPTP/MPP+-induced mitochondrial dysfunction and ROS production in vivo and in vitro. Food and Chemical Toxicology.49(1):271-80. (2011. 1)– IF 3.584
- 19. Jason Sheehan, Britney Popp, Stephen Monteith, Jessica Martin, Chris Cifarelli, Dae-Hee Lee, Deric Park, Trans sodium crocetinate: Functional Neuro-Imaging Studies in a Hypoxic Brain Tumor. Laboratory investigation. Journal of Neurosurgery. 115(4) 749-753 (2011, 10) – IF 3.443
- 20.Jie Lu, Alexander Ksendzovsky, Chunzhang Yang,Robert J. Weil,Dae-Hee Lee, Deric M. Park, Brian M.Balgley, Gautam U. Mehta, Cheng S. Lee, Russell R. Lonser,Zhengping Zhuang. CNTF receptor subunit is a marker for glioma cancer stem cells and correlates with tumor grade in primary brain tumors.Journal of Neurosurgery (2012, 12) 117(6) 1022-1031.– IF 3.44
- 21.DaeHee Lee,Tae Hwa Lee,Chang Hwa Jung, and Yong Ho Kim. Wogonin induces apoptosis by activating the AMPK and p53 signaling pathways in human glioblastoma cells. Cellular Signalling 24(11) 2. 216-2225.(2012, 11) IF 4.191
- 22. Tae Hwa Lee,Chang Hwa Jung, and Dae-Hee Lee.Neuroprotective Effects of Schisandrin BAgainst Transient Focal Cerebral Ischemia in Sprague-Dawley Rats. Food and Chemical Toxicology50(12) 4239-4245.(2012, 12)– IF 3.584
- 23. Chang Hwa Jung, Heemun Kim, Jiyun Ahn, Tae-Il Jeon, Dae-Hee Lee, Tae-Youl Ha, Fisetin regulates obesity by targeting mTORC1 signaling. Journal of Nutritional Biochemistry, (2013, 8) 24(8): 1547-1554.– IF 4.668
- 24. Dae-Hee Lee, Ying Zhang, Amin B. Kassam, Myung-Jin Park,Paul Gardner, Daniel M. Prevedello, Stephanie Henry, Craig Horbinski,Jan Beumer, Hussein Tawbi, Brian J. Williams, Mark E. Shaffrey, MerrillJ. Egorin, Roger Abounader, Deric M. Park. Preclinical Study of Combined PDGFR and HDAC Inhibition in Chordoma. PLosOne (2015, 8)– IF 3.057(제1저자)
- 25.Ruili Huang, Srilatha Sakamuru, Christopher Austin, DaeHee Lee, Sommer Josh, Kelley Michael, Alcort a David, Deric Park, Menghang Xia. Identification of Repurposed Small Molecule Drugs for Chordoma Therapy. Cancer Biology and Therapy(2013, 7) - 14(7):638-647.– IF 2.921
- 26.Brinda Gupta, Linda Chiang, KyungMin Chae, and DaeHee Lee. Phenethyl isothiocyanateinhibits hypoxia-induced accumulation of HIF-1α and VEGF e-x-p-r-e-s-s-i-o-n in human glioma cells. Food and Chemistry 141(3), 1841-1846 (2013, 5)– IF 4.052(교신저자)
- 27. Dae-Hee Lee, Chang Sup Lee, Kim DW, Ae JE, Tae-Hwa Lee, Digitoxin sensitizes glioma cells to TRAIL-mediated apoptosis by up-regulation of death receptor 5 and down-regulation of survivin. AntiCancer-Drugs 25(1), 44-52 (2014)– IF 2.268(제1저자)
- 28. Ying Zhang, Jungeun Kim, Adam Mueller, Bijan Dey, Yanzhi Yang, DaeHee Lee, JanHachmann, Sanjo Finderle, Deric Park, James Christensen, Benjamin Purow, AnindyaDutta, and Roger Abounader. Multiple receptor tyrosine kinases converge on microRNA134 to control KRAS, STAT5Band cancer stem cells. Cell Death and Differentiation 21(5), 720-734 (2014)– IF 8.218
- 29. Dae-Hee Lee, Chang Sup Lee, Tae-Hwa Lee. Phenethyl isothiocyanate sensitizes glioma cells to TRAIL-induced apoptosis. Biochem Biophys Res Commun. 446(4), 815-821 (2014. 3. 28)– IF 2.926(제1저자)
- 30.Lee D. H.,Kim DW, Jung CH, Lee YJ, Park D.Gingerol sensitizes TRAIL-induced apoptotic cell death of glioblastoma cells. Toxicol Appl Pharmacol. 2014 Sep 15;279(3):253-65.– IF 3.847(제1저자)
- 31.Lee D. H.,Kim SY, Song X, Bartlett DL, Kwon YT, Lee YJ.Role of Bcl-xL/Beclin-1 in synergistic apoptoticeffects of secretory TRAILarmed adenovirus in combination with mitomycin C and hyperthermia on colon cancer cells.Apoptosis.(2014. 11.1) 19(11)1603-1615.– IF 3.592(제1저자)
- 32.Lee D. H.,Ki Sa Sung, David L. Bartlett, Yong Tae Kwon, and Yong J. Lee, HSP90 inhibitor NVP-AUY922 enhances TRAIL-induced apoptosis by suppressing the JAK2-STAT3-Mcl- 1 signal transduction pathway in colorectal cancer cells. Cellular Signalling, (2015.1.25) 27(2):293-305.– IF 4.191(제1저자)
- 33. Lee D.H., Sung KS, Guo ZS, Kwon WT, Bartlett DL, Oh SC, Kwon YT, Lee YJ. TRAIL-Induced Caspase Activation is a Prerequisite for Activation of the Endoplasmic Reticulum Stress Induced Signal Transduction Pathways.J Cell Biochem. 2016. 117(5):1078-1091. – IF 3.446(제1저자)
- 34. Lee D. H., Ying Zhang, Amin B. Kassam, MyungJin Park,Paul Gardner, Daniel M.Prevedello,Stephanie Henry, Craig Horbinski,Jan Beumer, Hussein Tawbi, Brian J. Williams, Mark E. Shaffrey, Merrill J. Egorin, Roger Abounader, Deric M. Park. Preclinical Study of Combined PDGFR and HDAC Inhibition in Chordoma. PLosOne,2015 Aug 6;10(8):e0134426. – IF 3.057(제1저자)
- 35.Kim BR, Oh SC, Lee D.H., Kim JL, Lee SY, Kang MH, Lee SI, Kang S, Joung SY, Min BW. BMP-2 induces motility and invasiveness by promoting colon cancer stemness through STAT3 activation.Tumour Biol. 2015 Dec;36(12):9475-86. – IF 2.926
- 36. Park B, Lee J, Moon H, Lee G, Lee DH, Cho JH, Park D. Co-receptors are dispensable for tethering receptor-mediated phagocytosis of apoptotic cells. Cell Death Dis. 2015 May 28;6:e1772. doi: 10.1038/cddis.2015.140. – IF 5.378
- 37.Lee S, Moon H, Kim G, Cho JH, Lee D.H., Ye MB, Park D. Anion Transport or Nucleotide Binding by Ucp2 Is Indispensable for Ucp2-Mediated Efferocytosis.Mol Cells. 2015 Jul;38(7):657-62. – IF 2.670
- 38.Hwang JS, Lee HC, Oh SC, Kwon KH,Lee D.H., Shogaol overcomes TRAIL resistance in colon cancer cells via inhibiting of survivin.Tumour Biol. 2015 Nov;36(11):8819-29.– IF 2.926(교신저자)
- 39. Modulation of SQSTM1/p62 activity by N terminal arginylation of the endoplasmic reticulum chaperone HSPA5/GRP78/BiP.Cha Molstad H, Yu JE, Lee SH, Kim JG, Sung KS, Hwang J, Yoo YD, Lee YJ, Kim S T, Lee DH, Ciechanover A, Kim BY, Kwon YT.Autophagy. 2016 Jan 21: 12(2):426-8. – IF 8.593
- 40. Identification of a novel protein interaction between Elmo1 and Cdc27. Lee J, Moon B, Lee DH, Lee G, Park D.Biochem Biophys Res Commun. 2016 March 18: 471(4): 497-502. – IF 2.926
- 41. Lee DH, Kim JL, Na YJ, Kim BR, Jeong YA, Lee SI, Kang S, Joung SY, Lee SY, Oh SC, Min BW. Iron chelator induced apoptosis via the ER stress pathway in gastric cancer cells. Tumour Biol. 2016 Jul;37(7):9709-19. – IF 2.926(제1저자)
- 42. Lee DH, Park SH, Kim JL, Kim BR, Na YJ, Jo MJ, Jeong YA, Lee SY, Lee SI, Lee YY, Oh SC. Metformin enhances TRAIL-induced apoptosis by Mcl-1 degradation via Mule in colorectal cancer cells. Oncotarget. 2016 Sep 13; 7(37):59503-59518. – IF 5.168(제1저자)
- 43.Kim BR, Kang MH, Kim JL, Na YJ, Park SH, Lee SI, Kang S, Joung SY, Lee SY, Lee DH, Min BW, Oh SC.RUNX3 inhibits the metastasis and angiogenesis of colorectal cancer. Oncol Rep. 2016 Nov;36(5):2601-2608.(Co-correspond author) – IF 2.486(교신저자)
- 44. Dae-Hee Lee, Young Dong Yoo, Hyunjoo Cha-Molstad, Hyungsin Kim, Ki Sa Sung, Seung A Choi, Joonsung Hwang, Su Ran Mun, Changhoon Ji, Deric M. Park, Seung Ki Kim, Kyung-Jae Park, Shin-Hyuk Kang, Sang Cheul Oh, Aaron Ciechanover, Yong J. Lee, Bo Yeon Kim,and Yong Tae Kwon.Glioma-derived cancer stem cells are hypersensitive to proteasomal inhibition. (EMBO Reports, 2017 Jan;18(1):150-168.) – IF 8.568(제1저자)
- 45. Dae Hee Lee, Yoo Jin Na, Jung Lim Kim, Bo Ram Kim, Seong Hye Park, Min Jee Jo, Yoon A Jeong, Sang Cheul Oh. Cyclopamine sensitizes TRAIL-resistant gastric cancer cells to TRAIL- induced apoptosis via endoplasmic reticulum stress-mediated increase of death receptor 5 and survivin degradation. The International Journal of Biochemistry & Cell Biology (2017 Aug;89:147-156.) – IF 3.905 (제1저자)
- 46. Jung Soon Hwang, Ki Han Kwon, Dae-Hee Lee, DATS sensitizes glioma cells to TRAIL-mediated apoptosis by up-regulation of death receptor 5 via ROS. Food and Chemical Toxicology (2017. Aug;106(Pt A):514-521) – IF 3.977 (교신저자)
- 47. Lee DH, Lee SY, Oh SC. Hedgehog signaling pathway as a potential target in the treatment of advanced gastric cancer. Tumour Biol. 2017 Jun;39(6):1010428317692266. – IF 2.926 (제1저자)
- 48. Kim HJ, Jo MJ, Kim BR, Kim JL, Jeong YA, Na YJ, Park SH, Lee SY, Lee DH, Lee HS, Kim BH, Lee SI, Min BW, Yoo YD, Oh SC. Reactive oxygen species modulator 1 (Romo1) predicts unfavorable prognosis in colorectal cancer patients. PLoS One. 2017 May 4;12(5):e0176834.
- 49. Lee DH, Oh SC, Giles AJ, Jung J, Gilbert MR, Park DM. Cardiac glycosides suppress the maintenance of stemness and malignancy via inhibiting HIF1α in human glioma stem cells. Oncotarget. 2017 Jun 20;8(25):40233-40245. – IF 5.168 (제1저자)
- 50. Kim BR, Jeong YA, Na YJ, Park SH, Jo MJ, Kim JL, Jeong S, Lee SY, Kim HJ, Oh SC, Lee DH. Genipin suppresses colorectal cancer cells by inhibiting the Sonic Hedgehog pathway. Oncotarget. 2017 Oct 16;8(60):101952-101964. – IF 5.168 (교신저자)
- 51. Choi JY, Ryu J, Kim HJ, Song JW, Jeon JH, Lee DH, Oh DJ, Gweon DG, Oh WY, Yoo H, Park K, Kim JW. Therapeutic Effects of Targeted PPARɣ Activation on Inflamed High-Risk Plaques Assessed by Serial Optical Imaging In Vivo. Theranostics. 2018 Jan 1;8(1):45-60. – IF 8.537
- 52. Kang S, Oh SC, Min BW, Lee DH. Transglutaminase 2 Regulates Self-renewal and Stem Cell Marker of Human Colorectal Cancer Stem Cells. Anticancer Res. 2018 Feb;38(2):787-794. – IF 1.937 (교신저자)
- 53. Lee DH, Hong SH, Lee YS, Jo MJ, Jeong YA, Kwon WT, Choudry HA, Bartlett DL, Lee YJ. Molecular crosstalk between ferroptosis and apoptosis: emerging role of ER stress-induced p53-independent PUMA e-x-p-r-e-s-s-i-o-n. Oncotarget. 2017 Dec 8;8(70):115164-115178. – IF 5.168 (제1저자)
- 54. Lee DH, Kim D, Kim ST, Jeong S, Kim JL, Shim SM, Heo AJ, Song X, Guo ZS, Bartlett DL, Oh SC, Lee J, Saito Y, Kim BY, Kwon YT, Lee YJ. PARK7 modulates autophagic proteolysis through binding to the N-terminally arginylated form of the molecular chaperone HSPA5. Autophagy. 2018;14(11):1870-1885 (제1저자) – IF 16.016
- 55. Lee SY, Kim HJ, Oh SC, Lee DH. Genipin inhibits invasion and migration of colon cancer cells by suppression of HIF-1α accumulation and VEGF e-x-p-r-e-s-s-i-o-n. Food and Chemical Toxicology. 2018 Jun;116(Pt B):70-76. – IF 6.023 (교신저자)
- 56. Lee YS, Lee DH, Jeong SY, Park SH, Oh SC, Park YS, Yu J, Choudry HA, Bartlett DL, Lee YJ. Ferroptosis-inducing agents enhance TRAIL-induced apoptosis through upregulation of death receptor 5. Journal of Cellular Biochemistry. 2019 Jan;120(1):928-939. – IF 2.959 (제1저자)
- 57. Lee YS, Lee DH, Choudry HA, Bartlett DL, Lee YJ. Ferroptosis-Induced Endoplasmic Reticulum Stress: Cross-talk between Ferroptosis and Apoptosis. Molecular Cancer Research, 2018 Jul;16(7):1073-1076. IF 4.597 (제1저자)
- 58. Lee SY, Na YJ, Jeong YA, Kim JL, Oh SC, Lee DH. Upregulation of EphB3 in gastric cancer with acquired resistance to a FGFR inhibitor. Int J Biochem Cell Biol. 2018 Sep;102:128-137. (교신저자)
- 59. Kang S, Kim BR, Kang MH, Kim DY, Lee DH, Oh SC, Min BW, Um JW. Anti-metastatic effect of metformin via repression of interleukin 6-induced epithelial-mesenchymal transition in human colon cancer cells. PLoS One. 2018 Oct 11;13(10):e0205449. IF 2.766
- 60. Song X, Lee DH, Dilly AK, Lee YS, Choudry HA, Kwon YT, Bartlett DL, Lee YJ. Crosstalk Between Apoptosis and Autophagy Is Regulated by the Arginylated BiP/Beclin-1/p62 Complex. Molecular Cancer Research, 2018 Jul;16(7):1077-1091. IF 4.597
- 61. Yelithao K, Surayot U, Park W, Lee S, Lee DH, You S. Effect of sulfation and partial hydrolysis of polysaccharides from Polygonatum sibiricum on immune-enhancement. International Journal of Biological Macromolecules, 2018 Oct 16;122:10-18. IF 3.909
- 62. Park SH, Kim JL, Jeong S, Kim BR, Na YJ, Jo MJ, Yun HK, Jeong YA, Kim DY, Kim BG, You S, Oh SC, Lee DH. Codium fragile F2 sensitize colorectal cancer cells to TRAIL-induced apoptosis via c-FLIP ubiquitination. Biochemical and Biophysical Research Communications. 2019 Jan 1;508(1):1-8. IF 2.559 (교신저자)
- 63. Kim K, Lee J, Moon H, Lee SA, Kim D, Yang S, Lee DH, Lee G, Park D. The Intermolecular Interaction of Ephexin4 Leads to Autoinhibition by Impeding Binding of RhoG. Cells. 2018 Nov 15;7(11). IF 4.829
- 64. Lee J, Park B, Moon B, Park J, Moon H, Kim K, Lee SA, Kim D, Min C, Lee DH, Lee G, Park D. A scaffold for signaling of Tim-4-mediated efferocytosis is formed by fibronectin. Cell Death and Differentiation 2018 Nov 19. s41418-018-0238-9. IF 15.828
- 65. Kim HJ, Jo MJ, Kim BR, Kim JL, Jeong YA, Na YJ, Park SH, Lee SY, Lee DH, Kim BH, Yoo YD, Oh SC. Overe-x-p-r-e-s-s-i-o-n of Romo1 is an unfavorable prognostic biomarker and a predictor of lymphatic metastasis in non-small cell lung cancer patients. Onco Targets and Therapy 2018 Jul 23;11:4233-4246. IF 2.656
- 66. Hong Jun Kim, Sang Hee Kang, Byung Wook Min, Sang Cheul Oh, Dae-Hee Lee. Diallyl disulfide (DADS) boosts TRAIL-Mediated apoptosis in colorectal cancer cells by inhibiting Bcl-2. Food and Chemical Toxicology. 2019 Jan 22;125:354-360. (교신저자) – IF 6.023
- 67. Dae-Hee Lee, Jung Lim Kim, Soyeon Jeong, Bo Ram Kim, Yoo Jin Na, Seong Hye Park, Min Jee Jo, Yoon A Jeong, Sang Cheul Oh. Imatinib-induced apoptosis of gastric cancer cells is mediated by endoplasmic reticulum stress. Oncology Reposts. 2019 Mar 41(3):1616-1626. IF-2.976 (제1저자)
- 68. Kim BR, Park SH, Jeong YA, Na YJ, Kim JL, Jo MJ, Jeong S, Yun HK, Oh SC, Lee DH. RUNX3 enhances TRAIL-induced apoptosis by upregulating DR5 in colorectal cancer. Oncogene. 2019 May 38(20):3903-3918. IF-9.867 (교신저자)
- 69. Jeong S, Yun HK, Jeong YA, Jo MJ, Kang SH, Kim JL, Kim DY, Park SH, Kim BR, Na YJ, Lee SI, Kim HD, Kim DH, Oh SC, Lee DH. Cannabidiol-induced apoptosis is mediated by activation of Noxa in human colorectal cancer cells. Cancer Letters. 2019 Apr 10;447:12-23. (교신저자)- IF-8.679
- 70. Bo Ram Kim, YoonA Jeong, Min Jee Jo, Seong Hae Park, Hong Jun Kim, Yoo Jin Na, Jung Lim Kim, So Yeon Jeong, Sang Hee Kang, Dae-Hee Lee, Sang Cheul Oh. Genipin enhances the therapeutic effects of Oxaliplatin in colorectal cancer by upregulation of BIM. Molecular Cancer Therapy 2019 Apr;18(4):751-761 (교신저자) -IF 6.261
- 71. Seong Hye Park, Bo Ram Kim, Yoon A Jeong, Yoo Jin Na, Min Jee Jo, Jung Lim Kim, Soyeon Jeong, Sang Cheul Oh, Dae-Hee Lee, Sonic Hedgehog Pathway Activation is Associated with Cetuximab Resistance and EPHB3 Receptor Induction. Theranostics. 2019 April;9(8):2235-2251 (교신저자) - IF 11.556
- 72. Jung Lim Kim, Bo Ram Kim, Dae Young Kim, Yoon A Jeong, Soyeon Jeong, Yoo Jin Na, Seong Hye Park, Hye Kyeong Yun, Min Jee Jo, Bu Gyeom Kim, Han Do Kim, Dae Hyun Kim, Sang Cheul Oh, Sun Il Lee *, Dae-Hee Lee *. Cannabidiol enhances the therapeutic effects of TRAILby upregulating DR5 in colorectal cancer. Cancers (Basel). 2019 May 9;11(5):642. (교신저자) – IF 6.575
- 73. Jung Lim Kim, Seong Hae Park, Bo Ram Kim, YoonA Jeong, Min Jee Jo, Hong Jun Kim, Yoo Jin Na, So Yeon Jeong, Sang Hee Kang, Sang Cheul Oh, Dae-Hee Lee. Sea cucumber (Stichopus japonicas) F2 enhanced TRAIL-induced apoptosis via XIAP ubiquitination-ER stress in colorectal cancer cells. Nutrients. 2019 May 11;11(5):1061. (교신저자) – IF 5.717
- 74. Bo Ram Kim, Yoo Jin Na, Jung Lim Kim, Soyeon Jeong, Seong Hae Park, Min Jee Jo, Suk-young Lee, Yoon A Jeong, Hong Jun Kim, Sun Il Lee, Sang Cheul Oh, Dae-Hee Lee. RUNX3, a novel tumor suppressor function for the Hedgehog signaling via Gli-1 ubiquitination. Cell Death Differ. 2020 Feb;27(2):676-694. (교신저자) - IF 15.828
- 75. Jeong S, Kim BG, Kim DY, Kim BR, Kim JL, Park SH, Na YJ, Jo MJ, Yun HK, Jeong YA, Kim HJ, Lee SI, Kim HD, Kim DH, Oh SC, Lee DH. Cannabidiol Overcomes Oxaliplatin Resistance by Enhancing NOS3- and SOD2-Induced Autophagy in Human Colorectal Cancer Cells. Cancers (Basel). 2019 Jun 5;11(6):781. (교신저자) - IF 6.575
- 76. Jeong S, Kim DY, Kang SH, Yun HK, Kim JL, Kim BR, Park SH, Na YJ, Jo MJ, Jeong YA, Kim BG, Lee DH, Oh SC. Docosahexaenoic Acid Enhances Oxaliplatin-Induced Autophagic Cell Death via the ER Stress/Sesn2 Pathway in Colorectal Cancer. Cancers (Basel). 2019 Jul 14;11(7):982. (교신저자) - IF 6.575
- 77. Min Jee Jo; Soyeon Jeong; Hye Kyeong Yun; Dae Yeong Kim; Bo Ram Kim; Jung Lim Kim; Yoo Jin Na; Seong Hye Park; Yoon A Jeong; Bu Gyeom Kim; Hassan Ashktorab; Durane T Smoot; Jun Young Heo; Jeongsu Han; Dae-Hee Lee; Sang-Cheul Oh. Genipin induces mitochondrial dysfunction and apoptosis via downregulation of Stat3/Mcl-1 pathway in gastric cancer. BMC Cancer. 2019 Jul 27;19(1):739. (교신저자) - IF 3.150
- 78. Park SH, Jeong S, Kim BR, Jeong YA, Kim JL, Na YJ, Jo MJ, Yun HK, Kim DY, Kim BG, Lee DH, Oh SC. Activating CCT2 triggers Gli-1 activation during hypoxic condition in colorectal cancer. Oncogene. 2020 Jan;39(1):136-150. (교신저자) - IF 9.867
- 79. Jeong YA, Kim BR, Kim DY, Jeong S, Na YJ, Kim JL, Yun HK, Kim BG, Park SH, Jo MJ, Lee SI, Han BC, Lee DH, Oh SC. Korean Red Ginseng Extract Increases Apoptosis by Activation of the Noxa Pathway in Colorectal Cancer. Nutrients. 2019 Aug 29;11(9):2026.
- 80. Jeong S, Jo MJ, Yun HK, Kim DY, Kim BR, Kim JL, Park SH, Na YJ, Jeong YA, Kim BG, Ashktorab H, Smoot DT, Heo JY, Han J, Il Lee S, Do Kim H, Kim DH, Oh SC, Lee DH. Cannabidiol promotes apoptosis via regulation of XIAP/Smac in gastric cancer. Cell Death Dis. 2019 Nov 7;10(11):846. (교신저자) - IF 6.304
- 81. Na YJ, Kim BR, Kim JL, Kang S, Jeong YA, Park SH, Jo MJ, Kim JY, Kim HJ, Oh SC, Lee DH. Deficiency of 15-LOX-1 Induces Radioresistance through Downregulation of MacroH2A2 in Colorectal Cancer. Cancers (Basel). 2019 Nov 11;11(11):1776. (교신저자) - IF 6.575
- 82. Kim BR, Jeong YA, Kim DY, Kim JL, Jeong S, Na YJ, Yun HK, Park SH, Jo MJ, Ashktorab H, Smoot DT, Lee DH, Oh SC. Genipin increases oxaliplatin-induced cell death through autophagy in gastric cancer. J Cancer. 2020 Jan 1;11(2):460-467.
- 83. Woo M, Choi HI, Park SH, Ahn J, Jang YJ, Ha TY, Lee DH, Seo HD, Jung CH. The unc-51 like autophagy activating kinase 1-autophagy related 13 complex has distinct functions in tunicamycin-treated cells. Biochem Biophys Res Commun. 2020 Apr 9;524(3):744-749.
- 84. Na YJ, Yu ES, Kim DS, Lee DH, Oh SC, Choi CW. Metformin enhances the cytotoxic effect of nilotinib and overcomes nilotinib resistance in chronic myeloid leukemia cells. Korean J Intern Med. 2020 Apr 3. doi: 10.3904/kjim.2019.336.
- 85. Park SH, Choi HI, Ahn J, Jang YJ, Ha TY, Seo HD, Kim YS, Lee DH, Jung CH. Autophagy Functions to Prevent Methylglyoxal-Induced Apoptosis in HK-2 Cells. Oxid Med Cell Longev. 2020 Jun 4;2020:8340695.
- 86. Kang AR, Cho JH, Lee NG, Song JY, Hwang SG, Lee DH, Um HD, Park JK. RIP1 Is a Novel Component of γ-ionizing Radiation-Induced Invasion of Non-Small Cell Lung Cancer Cells. Int J Mol Sci. 2020 Jun 28;21(13):4584.
- 87. Min C, Park J, Kim G, Moon H, Lee SA, Kim D, Moon B, Yang S, Lee J, Kim K, Cho H, Park J, Lee DH, Lee G, Park D. Tim-4 functions as a scavenger receptor for phagocytosis of exogenous particles. Cell Death Dis. 2020 Jul 23;11(7):561.
- 88. Jo MJ, Kim BG, Park SH, Kim HJ, Jeong S, Kim BR, Kim JL, Na YJ, Jeong YA, Yun HK, Kim DY, Han J, Heo JY, Yoo YD, Lee DH, Oh SC. Romo1 Inhibition Induces TRAIL-Mediated Apoptosis in Colorectal Cancer. Cancers (Basel). 2020 Aug 20;12(9):2358. (교신저자) - IF 6.575
- 89. Kim JY, Kim HJ, Jung CW, Choi BI, Park MJ, Lee DH. PARK7 maintains the stemness of glioblastoma stem cells by stabilizing epidermal growth factor receptor variant III. Oncogene. 2021 Jan;40(3):508-521. (교신저자) - IF 9.867
- 90. Kim D, Moon H, Cho H, Min C, Moon B, Yang S, Lee J, Lee SA, Park H, Lee DH, Jeong D, Lee G, Park D. Apoptotic Cells Trigger Calcium Entry in Phagocytes by Inducing the Orai1-STIM1 Association. Cells. 2021 Oct 9;10(10):2702
- 91. Jo MJ, Kim BG, Kim WY, Yun HK, Jeong S, Park SH, Kim BR, Kim JL, Kim DY, Lee SI, Oh SC, Lee DH. Cannabidiol Suppresses Angiogenesis and Stemness of Breast Cancer Cells by Downregulation of Hypoxia-Inducible Factors-1α. Cancers (Basel). 2021 Nov 12;13(22):5667. (교신저자) - IF 6.575
- 92. Han M, Ryu G, Shin SA, An J, Kim H, Park D, Lee DH, Lee CS. Physiological Roles of Apoptotic Cell Clearance: Beyond Immune Functions. Life (Basel). 2021 Oct 26;11(11):1141.
- 93. Rahimizadeh P, Lee JE, In Lim S, Lee DH. An albumin scaffold grafted with an alpha-helical motif delivers therapeutic payloads by modular coiled-coil assembly. Int J Biol Macromol. 2022 Feb 11;205:376-384. (교신저자)- IF 6.953
- 94. Jeong S, Farag AK, Yun HK, Jeong YA, Kim DY, Jo MJ, Park SH, Kim BR, Kim JL, Kim BG, Lee DH, Roh EJ, Oh SC. AF8c, a Multi-Kinase Inhibitor Induces Apoptosis by Activating DR5/Nrf2 via ROS in Colorectal Cancer Cells. Cancers (Basel). 2022 Jun 21;14(13):3043. (교신저자)- IF 6.575
- 95. Kim JL, Lee DH, Pan CH, Park SJ, Oh SC, Lee SY. Role of phloretin as a sensitizer to TRAIL-induced apoptosis in colon cancer. Oncol Lett. 2022 Jul 19;24(3):321. (제1저자) - IF
특허
- 1. Lee, D. H., Kim, S. H., Lee, S. Y., Choi, C., Jun, W. J., Shin, D. H., Cho, H. Y., and Hong, B. S. Extract from Gelidium amansii Having Gut Immunity Activity and Method Therefore. Korea patent pending, the application number: 10-2003-0070671, Oct 10, 2003
- 2. Lee, D.H., Ha, N. N., Bu, Jung, J. H., Y. M., Kim, M. Y., and Kim, H. C. Composition comprising oleic acid having neuronal cell-protecting activity for preventing and treating the degenerative brain disease. Korea patent pending, the application number: 10-2005-0076324, Sept 12
- 3. 오상철, 오상욱, 이대희. 복수의 의료 영상에서의 동일 병변 영역 추적 장치 및 방법 (2017-0047267)
- 4. 오상철, 오상욱, 이대희. 환자 맞춤형 진단 보조 정보 제공 시스템, 장치 및 방법 (2017-008092)
- 5. 이대희, 오상철, 조민지 , Romo1 억제제를 포함하는 TRAIL에 대한 감수성 증진용 조성물 (10-2017-012187)
- 6. 이대희, 오상철, 박성혜, 항암제 내성 진단용 바이오마커 및 이의 용도 (10-2017-0126168)
- 7. 이대희, 오상철, 조민지, RUNX3 단백질 또는 이를 코딩하는 RUNX3 유전자를 포함하는 암 예방 또는 치료용 약학 조성물 (2017-0162891)
- 8. 이대희, 오상철, 유상권, 박성혜, 해삼추출물또는이의분획물, 및 TRAIL 단백질을포함하는암예방또는치료용조성물 (2018-0003262)
- 9. 이대희, 오상철, 유상권, 김정림, 박성혜, 청각 추출물 또는 이의 분획물, 및 TRAIL 단백질을 포함하는 암 예방 또는 치료용 조성물 (2018-0003261)
- 10. 이대희, 오상철, 다이알릴 다이설파이드 및 TRAIL 단백질을 포함하는 암 예방 또는 치료용 조성물 (2018-0041452)
- 11. 이대희, 오상철, 카나비디올 추출물 및 트레일을 함유하는 대장암 예방 또는 치료용 약학 조성물 (2018-0018830)
- 12. 이대희, 오상철, 칸나비디올 추출물을 함유하는 대장암 예방 또는 치료용 약학 조성물 (2018-0018829)