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이대희

  • 성명 : 이대희
  • 전공 : 식품생화학
  • 연구분야 : 해양천연물 기능성 식의약품소재 연구
  • 연구실 : 식의약소재생화학 연구실
  • 전화번호 : 033-640-2347
  • 이메일 : neogene@gwnu.ac.kr

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학력

고려대학교 식품공학과 학사 고려대학교 생명공학원 식품생물학 석사​ 고려대학교 생명공학원 식품생명공학 박사

경력

2009.9 ~ 현재 강릉원주대 생명과학대학 해양식품공학과 교수 2015.2 ~ 2019.8 고려대학교 의과대학 의과학대학원 연구교수 2014.2 ~ 2015.1 University of Pittsburgh Hillman Cancer Center 연구교수 2010.4 ~ 2014.1 University of Virginia 신경외과 (뇌종양 항암제개발) 책임연구원 2006.8 ~ 2010.3 University of Pittsburgh Hillman Cancer Center 책임연구원 2005.3 ~ 2006.7 경희대학교 한의과대학 본초학 연구실 박사 후 연구원

전문연구분야

1. In vivo 마우스 시스템을 이용한 항암제 개발 연구 2. 해양생물 유래 의약품 소재 개발에 관한 연구 3. 항염, 항산화, 항알러지(아토피 및 여드름), 항암 및 퇴행성뇌질환 연구 4. In vivo 모델 적용을 통한 천연물 소재의 기능성 검증 및 생물학적 유용성(bioavailability) 연구

주요논문

1. Lee, D. H., Jun, W. J., Shin, D. H., Cho, H. Y., and Hong, B. S.Effect of Culture Conditions on Production of 5-Aminolevulinic Acid by Recombinant Escherichia coli. Bioscience, Biotechnology, and Biochemistry. 69(3): 470-476. (2005) 2. Lee, D. H., Jun, W. J., Yoon, J. W., Cho, H. Y., and Hong, B. S.Process Strategies to Enhance the Production of 5-Aminolevulinic Acid with Recombinant E.coli.J. Microbiol. Biotechnol. 14(6): 1310-1317. (2004) 3. Jun, W. J., Kim, S. H., Lee, D. H., Jung, J. W., Shim, S. I., Lee, K. W., Cho, H. Y., and Hong, B. S.In Vitro and In Vivo Effects of Gelidium amansii on Intestinal Immune System. Food Science and Biotechnology.14(1): 147-151. (2005) 4.Lee, D. H., Jun, W. J., Kim, K. M., Shin, D. H., Cho, H. Y., and Hong, B. S. Inhibition of 5-aminolevulenic acid dehydratase in recombinant Escherichia coli using D-glucose. Enzyme and Microbial Technology 32: 27-34. (2003) 5. Lee, D. H, Ha, N., Bu, Y.M., Choi, H.I., Park, Y.G.,Kim, Y.B., Kim, M.Y., and Kim, H. Neuroprotective effect of Buddleja officinalis extracton transient middle cerebral artery occlusion in rats.Biol. Pharm. Bull. 29(8): 1608-1612. (2006) 6.Bu, Y. M.,Lee, D. H, Kim, M.Y.,Oh, S., Hwang, M.,Chung, J.,Jin, Z., and Kim, H. Neuroprotective effect of Neubo153 on Transient Focal Cerebral Ischemia in Rats. The Korea Journal of Herbology, 21(2): 151-158. (2006) 7.Bu, Y., Rho, S., Kim, J., Kim, M.Y., Lee, D.H., Kim, S.Y., Choi, H., and Kim, H.Neuroprotective effect of tyrosol on transient focalcerebral ischemia in rats. Neuroscience letter. 414(3):218-21.) (2007) 8. Chung, H., Lee, D.H., Kim, E., Seo, S., Ju, S., Lee, D., Kim, H., andPark, S.Ghrelin Inhibits Apoptosis in Hypothalamic NeuronalCells during Oxygen-Glucose Deprivation. Endocrinology 148(1):148–159. (2007) 9. Kim, Y. H.,Lee, D. H.,Jeong, J. H.,Zong Sheng Guo, and Lee,Y. J. Quercetin augments TRAIL-induced apoptotic death: involvement of the ERK signal transduction pathway. Biochemical Pharmacology, 75(10):1946-1958. (2008)– IF 5.091 10. Lee, D. H.,Kim, Clifford., Zhang, Lin., and Lee,Y. J. Role of p53, PUMA, and Bax in wogonin-induced apoptosis in human cancer cells. Biochemical Pharmacology, 75(10):2020-2033. (2008)– IF 5.091 11. Lee, D. H.,Miroslaw Szczepanski,and Lee,Y. J. Role of Bax in quercetin-induced apoptosis in human cancer cells. Biochemical Pharmacology,15;75(12):2345-55. (2008)– IF 5.091 12. Lee, D. H.,and Lee,Y. J. Quercetin suppresses hypoxia-induced accumulation ofhypoxia-inducible factor-1α (HIF-1α)through inhibiting protein synthesis, Journal of Cellular Biochemistry. (May-2008)- Accepted.– IF 3.446 13. Lee, D. H., Miroslaw Szczepanski, and Lee, Y. J. Magnolol induces apoptosis via inhibiting the EGFR/PI3K/Akt signaling pathway in human prostate cancer cells. Journal of Cellular Biochemistry. 106(6):1113-1122. (2009). – IF 3.446 14.Lee D. H., Juong G. Rhee and Yong J. Lee.Reactive oxygen species upregulate p53 and PUMA; a possible mechanism for apoptosis during combined treatment with TRAIL and wogonin. British Journal ofPharm acology.157(7):1189-202 (2009). 15.Soeda A, Park M, Lee D,Mintz A, Androutsellis-Theotokis A, McKay RD, Engh J, Iwama T, Kunisada T, Kassam AB, Pollack IF, Park DM. Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF- 1alpha. Oncogene. 12;28(45):3949-59 (2009) – IF 7.932 16.Marco A. Alcala, Jr, Kyungsoo Park, Jinsang Yoo, Dae-Hee Lee, Bae-hang Park, Byeong-Chel Lee, David L. Bartlett, and Yong J. Lee. Effect of hyperthermia in combination with TRAIL on the JNK-Bim signal transduction pathway and growth of xenograft tumors. Journal of Cellular Biochemistry.106(6):1113-1122. (2010).– IF 3.446 17.Dae-Hee Lee,Lee Yong J, andKi Han Kwon. Neuroprotective effects of astaxanthin in oxygen-glucose deprivation in SH-SY5Y cells and global cerebral ischemia in rat. Journal of Clinical Biochemistry and Nutrition.47:121-129. (2010). – IF 1.164 18.Dae-Hee Lee andCuk-Seong Kim, and Yong J. Lee. Astaxanthin protects against MPTP/MPP+-induced mitochondrial dysfunction and ROS production in vivo and in vitro. Food and Chemical Toxicology.49(1):271-80. (2011. 1)– IF 3.584 19. Jason Sheehan, Britney Popp, Stephen Monteith, Jessica Martin, Chris Cifarelli, Dae-Hee Lee, Deric Park, Trans sodium crocetinate: Functional Neuro-Imaging Studies in a Hypoxic Brain Tumor. Laboratory investigation. Journal of Neurosurgery. 115(4) 749-753 (2011, 10) – IF 3.443 20.Jie Lu, Alexander Ksendzovsky, Chunzhang Yang,Robert J. Weil,Dae-Hee Lee, Deric M. Park, Brian M.Balgley, Gautam U. Mehta, Cheng S. Lee, Russell R. Lonser,Zhengping Zhuang. CNTF receptor subunit is a marker for glioma cancer stem cells and correlates with tumor grade in primary brain tumors.Journal of Neurosurgery (2012, 12) 117(6) 1022-1031.– IF 3.44 21.DaeHee Lee,Tae Hwa Lee,Chang Hwa Jung, and Yong Ho Kim. Wogonin induces apoptosis by activating the AMPK and p53 signaling pathways in human glioblastoma cells. Cellular Signalling 24(11) 2. 216-2225.(2012, 11) IF 4.191 22. Tae Hwa Lee,Chang Hwa Jung, and Dae-Hee Lee.Neuroprotective Effects of Schisandrin BAgainst Transient Focal Cerebral Ischemia in Sprague-Dawley Rats. Food and Chemical Toxicology50(12) 4239-4245.(2012, 12)– IF 3.584 23. Chang Hwa Jung, Heemun Kim, Jiyun Ahn, Tae-Il Jeon, Dae-Hee Lee, Tae-Youl Ha, Fisetin regulates obesity by targeting mTORC1 signaling. Journal of Nutritional Biochemistry, (2013, 8) 24(8): 1547-1554.– IF 4.668 24. Dae-Hee Lee, Ying Zhang, Amin B. Kassam, Myung-Jin Park,Paul Gardner, Daniel M. Prevedello, Stephanie Henry, Craig Horbinski,Jan Beumer, Hussein Tawbi, Brian J. Williams, Mark E. Shaffrey, MerrillJ. Egorin, Roger Abounader, Deric M. Park. Preclinical Study of Combined PDGFR and HDAC Inhibition in Chordoma. PLosOne (2015, 8)– IF 3.057(제1저자) 25.Ruili Huang, Srilatha Sakamuru, Christopher Austin, DaeHee Lee, Sommer Josh, Kelley Michael, Alcort a David, Deric Park, Menghang Xia. Identification of Repurposed Small Molecule Drugs for Chordoma Therapy. Cancer Biology and Therapy(2013, 7) - 14(7):638-647.– IF 2.921 26.Brinda Gupta, Linda Chiang, KyungMin Chae, and DaeHee Lee. Phenethyl isothiocyanateinhibits hypoxia-induced accumulation of HIF-1α and VEGF expression in human glioma cells. Food and Chemistry 141(3), 1841-1846 (2013, 5)– IF 4.052(교신저자) 27. Dae-Hee Lee, Chang Sup Lee, Kim DW, Ae JE, Tae-Hwa Lee, Digitoxin sensitizes glioma cells to TRAIL-mediated apoptosis by up-regulation of death receptor 5 and down-regulation of survivin. AntiCancer-Drugs 25(1), 44-52 (2014)– IF 2.268(제1저자) 28. Ying Zhang, Jungeun Kim, Adam Mueller, Bijan Dey, Yanzhi Yang, DaeHee Lee, JanHachmann, Sanjo Finderle, Deric Park, James Christensen, Benjamin Purow, AnindyaDutta, and Roger Abounader. Multiple receptor tyrosine kinases converge on microRNA134 to control KRAS, STAT5Band cancer stem cells. Cell Death and Differentiation 21(5), 720-734 (2014)– IF 8.218 29. Dae-Hee Lee, Chang Sup Lee, Tae-Hwa Lee. Phenethyl isothiocyanate sensitizes glioma cells to TRAIL-induced apoptosis. Biochem Biophys Res Commun. 446(4), 815-821 (2014. 3. 28)– IF 2.926(제1저자) 30.Lee D. H.,Kim DW, Jung CH, Lee YJ, Park D.Gingerol sensitizes TRAIL-induced apoptotic cell death of glioblastoma cells. Toxicol Appl Pharmacol. 2014 Sep 15;279(3):253-65.– IF 3.847(제1저자) 31.Lee D. H.,Kim SY, Song X, Bartlett DL, Kwon YT, Lee YJ.Role of Bcl-xL/Beclin-1 in synergistic apoptoticeffects of secretory TRAILarmed adenovirus in combination with mitomycin C and hyperthermia on colon cancer cells.Apoptosis.(2014. 11.1) 19(11)1603-1615.– IF 3.592(제1저자) 32.Lee D. H.,Ki Sa Sung, David L. Bartlett, Yong Tae Kwon, and Yong J. Lee, HSP90 inhibitor NVP-AUY922 enhances TRAIL-induced apoptosis by suppressing the JAK2-STAT3-Mcl- 1 signal transduction pathway in colorectal cancer cells. Cellular Signalling, (2015.1.25) 27(2):293-305.– IF 4.191(제1저자) 33. Lee D.H., Sung KS, Guo ZS, Kwon WT, Bartlett DL, Oh SC, Kwon YT, Lee YJ. TRAIL-Induced Caspase Activation is a Prerequisite for Activation of the Endoplasmic Reticulum Stress Induced Signal Transduction Pathways.J Cell Biochem. 2016. 117(5):1078-1091. – IF 3.446(제1저자) 34. Lee D. H., Ying Zhang, Amin B. Kassam, MyungJin Park,Paul Gardner, Daniel M.Prevedello,Stephanie Henry, Craig Horbinski,Jan Beumer, Hussein Tawbi, Brian J. Williams, Mark E. Shaffrey, Merrill J. Egorin, Roger Abounader, Deric M. Park. Preclinical Study of Combined PDGFR and HDAC Inhibition in Chordoma. PLosOne,2015 Aug 6;10(8):e0134426. – IF 3.057(제1저자) 35.Kim BR, Oh SC, Lee D.H., Kim JL, Lee SY, Kang MH, Lee SI, Kang S, Joung SY, Min BW. BMP-2 induces motility and invasiveness by promoting colon cancer stemness through STAT3 activation.Tumour Biol. 2015 Dec;36(12):9475-86. – IF 2.926 36. Park B, Lee J, Moon H, Lee G, Lee DH, Cho JH, Park D. Co-receptors are dispensable for tethering receptor-mediated phagocytosis of apoptotic cells. Cell Death Dis. 2015 May 28;6:e1772. doi: 10.1038/cddis.2015.140. – IF 5.378 37.Lee S, Moon H, Kim G, Cho JH, Lee D.H., Ye MB, Park D. Anion Transport or Nucleotide Binding by Ucp2 Is Indispensable for Ucp2-Mediated Efferocytosis.Mol Cells. 2015 Jul;38(7):657-62. – IF 2.670 38.Hwang JS, Lee HC, Oh SC, Kwon KH,Lee D.H., Shogaol overcomes TRAIL resistance in colon cancer cells via inhibiting of survivin.Tumour Biol. 2015 Nov;36(11):8819-29.– IF 2.926(교신저자) 39. Modulation of SQSTM1/p62 activity by N terminal arginylation of the endoplasmic reticulum chaperone HSPA5/GRP78/BiP.Cha Molstad H, Yu JE, Lee SH, Kim JG, Sung KS, Hwang J, Yoo YD, Lee YJ, Kim S T, Lee DH, Ciechanover A, Kim BY, Kwon YT.Autophagy. 2016 Jan 21: 12(2):426-8. – IF 8.593 40. Identification of a novel protein interaction between Elmo1 and Cdc27. Lee J, Moon B, Lee DH, Lee G, Park D.Biochem Biophys Res Commun. 2016 March 18: 471(4): 497-502. – IF 2.926 41. Lee DH, Kim JL, Na YJ, Kim BR, Jeong YA, Lee SI, Kang S, Joung SY, Lee SY, Oh SC, Min BW. Iron chelator induced apoptosis via the ER stress pathway in gastric cancer cells. Tumour Biol. 2016 Jul;37(7):9709-19. – IF 2.926(제1저자) 42. Lee DH, Park SH, Kim JL, Kim BR, Na YJ, Jo MJ, Jeong YA, Lee SY, Lee SI, Lee YY, Oh SC. Metformin enhances TRAIL-induced apoptosis by Mcl-1 degradation via Mule in colorectal cancer cells. Oncotarget. 2016 Sep 13; 7(37):59503-59518. – IF 5.168(제1저자) 43.Kim BR, Kang MH, Kim JL, Na YJ, Park SH, Lee SI, Kang S, Joung SY, Lee SY, Lee DH, Min BW, Oh SC.RUNX3 inhibits the metastasis and angiogenesis of colorectal cancer. Oncol Rep. 2016 Nov;36(5):2601-2608.(Co-correspond author) – IF 2.486(교신저자) 44. Dae-Hee Lee, Young Dong Yoo, Hyunjoo Cha-Molstad, Hyungsin Kim, Ki Sa Sung, Seung A Choi, Joonsung Hwang, Su Ran Mun, Changhoon Ji, Deric M. Park, Seung Ki Kim, Kyung-Jae Park, Shin-Hyuk Kang, Sang Cheul Oh, Aaron Ciechanover, Yong J. Lee, Bo Yeon Kim,and Yong Tae Kwon.Glioma-derived cancer stem cells are hypersensitive to proteasomal inhibition. (EMBO Reports, 2017 Jan;18(1):150-168.) – IF 8.568(제1저자) 45. Dae Hee Lee, Yoo Jin Na, Jung Lim Kim, Bo Ram Kim, Seong Hye Park, Min Jee Jo, Yoon A Jeong, Sang Cheul Oh. Cyclopamine sensitizes TRAIL-resistant gastric cancer cells to TRAIL- induced apoptosis via endoplasmic reticulum stress-mediated increase of death receptor 5 and survivin degradation. The International Journal of Biochemistry & Cell Biology (2017 Aug;89:147-156.) – IF 3.905(제1저자) 46.Jung Soon Hwang,Ki Han Kwon,Dae-Hee Lee,DATS sensitizes glioma cells to TRAIL-mediated apoptosis by up-regulation of death receptor 5 via ROS.Food Chemical and Toxicology (2017. Aug;106(Pt A):514-521) – IF 3.977(교신저자) 47.Lee DH, Lee SY, Oh SC. Hedgehog signaling pathway as a potential target in the treatment of advanced gastric cancer. Tumour Biol. 2017 Jun;39(6):1010428317692266.– IF 2.926(제1저자) 48. Kim HJ, Jo MJ, Kim BR, Kim JL, Jeong YA, Na YJ, Park SH, Lee SY, Lee DH, Lee HS, Kim BH, Lee SI, Min BW, Yoo YD, Oh SC. Reactive oxygen species modulator 1 (Romo1) predicts unfavorable prognosis in colorectal cancer patients. PLoS One. 2017 May 4;12(5):e0176834. 49.Lee DH,Oh SC, Giles AJ, Jung J, Gilbert MR, Park DM. Cardiac glycosides suppress the maintenance of stemness and malignancy via inhibiting HIF1α in human glioma stem cells. Oncotarget. 2017 Jun 20;8(25):40233-40245.– IF 5.168(제1저자) 50. Kim BR, Jeong YA, Na YJ, Park SH, Jo MJ, Kim JL, Jeong S, Lee SY, Kim HJ, Oh SC, Lee DH. Genipin suppresses colorectal cancer cells by inhibiting the Sonic Hedgehog pathway.Oncotarget. 2017 Oct 16;8(60):101952-101964. – IF 5.168(교신저자) 51. Choi JY, Ryu J, Kim HJ, Song JW, Jeon JH, Lee DH, Oh DJ, Gweon DG, Oh WY, Yoo H, Park K, Kim JW.Therapeutic Effects of Targeted PPARɣ Activation on Inflamed High-Risk Plaques Assessed by Serial Optical Imaging In Vivo.Theranostics. 2018 Jan 1;8(1):45-60. – IF 8.537 52. Kang S, Oh SC, Min BW, Lee DH. Transglutaminase 2 Regulates Self-renewal and Stem Cell Marker of Human Colorectal Cancer Stem Cells.Anticancer Res. 2018 Feb;38(2):787-794. – IF 1.937(교신저자) 53. Lee DH,Hong SH, Lee YS, Jo MJ, Jeong YA, Kwon WT, Choudry HA, Bartlett DL, Lee YJ. Molecular crosstalk between ferroptosis and apoptosis: emerging role of ER stress-induced p53-independent PUMA expression.Oncotarget. 2017 Dec 8;8(70):115164-115178. – IF 5.168(제1저자) 54.Lee DH, Kim D, Kim ST, Jeong S, Kim JL, Shim SM, Heo AJ, Song X, Guo ZS, Bartlett DL, Oh SC, Lee J, Saito Y, Kim BY, Kwon YT, Lee YJ. PARK7 modulates autophagic proteolysis through binding to the N-terminally arginylated form of the molecular chaperone HSPA5.Autophagy. 2018;14(11):1870-1885– IF 11.01(제1저자) 55.Lee SY, Kim HJ, Oh SC, Lee DH.Genipin inhibits invasion and migration of colon cancer cells by suppression of HIF-1α accumulation and VEGF expression. Food Chemical and Toxicology.2018 Jun;116(Pt B):70-76. – IF 3.977(교신저자) 56.Lee YS, Lee DH, Jeong SY, Park SH, Oh SC, Park YS, Yu J, Choudry HA, Bartlett DL, Lee YJ. Ferroptosis-inducing agents enhance TRAIL-induced apoptosis through upregulation of death receptor 5.Journal of Cellular Biochemistry. 2019 Jan;120(1):928-939. – IF 2.959(제1저자) 57. Lee YS, Lee DH, Choudry HA, Bartlett DL, Lee YJ. Ferroptosis-Induced Endoplasmic Reticulum Stress: Cross-talk between Ferroptosis and Apoptosis.Molecular Cancer Research, 2018 Jul;16(7):1073-1076. IF 4.597 (제1저자) 58.Lee SY, Na YJ, Jeong YA, Kim JL, Oh SC, Lee DH. Upregulation of EphB3 in gastric cancer with acquired resistance to a FGFR inhibitor.Int J Biochem Cell Biol. 2018 Sep;102:128-137.(교신저자) 59. Kang S, Kim BR, Kang MH, Kim DY, Lee DH, Oh SC, Min BW, Um JW. Anti-metastatic effect of metformin via repression of interleukin 6-induced epithelial-mesenchymal transition in human colon cancer cells.PLoS One. 2018 Oct 11;13(10):e0205449.IF 2.766 60. Song X, Lee DH, Dilly AK, Lee YS, Choudry HA, Kwon YT, Bartlett DL, Lee YJ. Crosstalk Between Apoptosis and Autophagy Is Regulated by the Arginylated BiP/Beclin-1/p62 Complex.Molecular Cancer Research, 2018 Jul;16(7):1077-1091. IF 4.597 61. Yelithao K, Surayot U, Park W, Lee S, Lee DH, You S. Effect of sulfation and partial hydrolysis of polysaccharides from Polygonatum sibiricum on immune-enhancement.International Journal of Biological Macromolecules, 2018 Oct 16;122:10-18.IF 3.909 62. Park SH, Kim JL, Jeong S, Kim BR, Na YJ, Jo MJ, Yun HK, Jeong YA, Kim DY, Kim BG, You S, Oh SC, Lee DH. Codium fragile F2 sensitize colorectal cancer cells to TRAIL-induced apoptosis via c-FLIP ubiquitination.Biochemical and Biophysical Research Communications. 2019 Jan 1;508(1):1-8.IF 2.559 (교신저자) 63.Kim K, Lee J, Moon H, Lee SA, Kim D, Yang S, Lee DH, Lee G, Park D. The Intermolecular Interaction of Ephexin4 Leads to Autoinhibition by Impeding Binding of RhoG.Cells. 2018 Nov 15;7(11). IF 4.829 64.Lee J, Park B, Moon B, Park J, Moon H, Kim K, Lee SA, Kim D, Min C, Lee DH, Lee G, Park D. A scaffold for signaling of Tim-4-mediated efferocytosis is formed by fibronectin.Cell Death and Differentiation2018 Nov 19.s41418-018-0238-9.IF 8.0 65. Kim HJ, Jo MJ, Kim BR, Kim JL, Jeong YA, Na YJ, Park SH, Lee SY, Lee DH, Kim BH, Yoo YD, Oh SC. Overexpression of Romo1 is an unfavorable prognostic biomarker and a predictor of lymphatic metastasis in non-small cell lung cancer patients.Onco Targets and Therapy 2018 Jul 23;11:4233-4246. IF 2.656 66. Hong Jun Kim, Sang Hee Kang, Byung Wook Min,Sang Cheul Oh, Dae-Hee Lee.Diallyl disulfide (DADS) boosts TRAIL-Mediated apoptosis in colorectal cancer cells by inhibiting Bcl-2.Food Chemical and Toxicology.2019 Jan 22;125:354-360. – IF 3.977(교신저자) 67. Dae-Hee Lee, Jung Lim Kim, Soyeon Jeong, Bo Ram Kim, Yoo Jin Na, Seong Hye Park, Min Jee Jo, Yoon A Jeong, Sang Cheul Oh. Imatinib-induced apoptosis of gastric cancer cells is mediated by endoplasmic reticulum stress. Oncology Reposts. 2019 Mar 41(3):1616-1626. IF-2.976(제1저자) 68. Kim BR, Park SH, Jeong YA, Na YJ, Kim JL, Jo MJ, Jeong S, Yun HK, Oh SC, Lee DH. RUNX3 enhances TRAIL-induced apoptosis by upregulating DR5 in colorectal cancer. Oncogene. 2019 Jan 28,s41388-019-0693-x.IF-6.854(교신저자) 69. Jeong S, Yun HK, Jeong YA, Jo MJ, Kang SH, Kim JL, Kim DY, Park SH, Kim BR, Na YJ, Lee SI, Kim HD, Kim DH, Oh SC, Lee DH. Cannabidiol-induced apoptosis is mediated by activation of Noxa in human colorectal cancer cells.Cancer Letters. 2019 Jan 18;447:12-23.IF-6.491(교신저자) 70. Bo Ram Kim,YoonA Jeong, Min Jee Jo, Seong Hae Park, Hong Jun Kim,Yoo Jin Na, Jung Lim Kim, SoYeonJeong, Sang Hee Kang, Dae-Hee Lee,Sang Cheul Oh.Genipin enhances the therapeutic effects of Oxaliplatin in colorectal cancer by upregulation of BIM. Molecular Cancer Therapy2019 Apr;18(4):751-761-IF 5.365(교신저자) 71.Seong Hye Park, Bo Ram Kim, Yoon A Jeong, Yoo Jin Na, Min Jee Jo, Jung Lim Kim, Soyeon Jeong, Sang Cheul Oh, Dae-Hee Lee, Sonic Hedgehog Pathway Activation is Associated with Cetuximab Resistance and EPHB3 Receptor Induction. Theranostics.2019 April;9(8):2235-2251 -IF 8.537(교신저자) 72. Jung Lim Kim, Bo Ram Kim, Dae Young Kim, Yoon A Jeong, Soyeon Jeong, Yoo Jin Na, Seong Hye Park, Hye Kyeong Yun, Min Jee Jo, Bu Gyeom Kim, Han Do Kim, Dae Hyun Kim, Sang Cheul Oh, Sun Il Lee, Dae-Hee Lee. Cannabidiol enhances the therapeutic effects of TRAILby upregulating DR5 in colorectal cancer. Cancers (Basel). 2019 May 9;11(5). pii: E642– IF 5.326 (교신저자) 73. Jung Lim Kim, Seong Hae Park, Bo Ram Kim, YoonA Jeong, Min Jee Jo, Hong Jun Kim, Yoo Jin Na, So Yeon Jeong, Sang Hee Kang, Sang Cheul Oh, Dae-Hee Lee. Sea cucumber (Stichopus japonicas) F2 enhanced TRAIL-induced apoptosis via XIAP ubiquitination-ER stress in colorectal cancer cells.Nutrients. 2019 May 11;11(5). pii: E1061– IF 4.196 (교신저자) 74. Jeong S, Kim BG, Kim DY, Kim BR, Kim JL, Park SH, Na YJ, Jo MJ, Yun HK, Jeong YA, Kim HJ, Lee SI, Kim HD, Kim DH, Oh SC, Lee DH. Cannabidiol Overcomes Oxaliplatin Resistance by Enhancing NOS3- and SOD2-Induced Autophagy in Human Colorectal Cancer Cells.Cancers (Basel). 2019 Jun 5;11(6). pii: E781. (교신저자) 75. Bo Ram Kim, Yoo Jin Na, Jung Lim Kim, Soyeon Jeong, Seong Hae Park, Min Jee Jo, Suk-young Lee, Yoon A Jeong, Hong Jun Kim, Sun Il Lee, Sang Cheul Oh, Dae-Hee Lee.RUNX3, a novel tumor suppressor function for the Hedgehog signaling via Gli-1 ubiquitination. Cell Death and Differentiation. 2019 Jul 5.(교신저자) 76. Lim H, Back SM, Hwang MH, Lee DH, Choi H, Nam J. Sheathless High-Throughput Circulating Tumor Cell Separation Using Viscoelastic non-Newtonian Fluid. Micromachines (Basel). 2019 Jul 10;10(7). IF-2.222 77. Soyeon Jeong, Dae Yeong Kim,Hye Kyeong Yun, Jung Lim Kim, Bo Ram Kim,Seong Hye Park, Yoo Jin Na, Min Jee Jo, Yoon A Jeong,Bu Gyeom Kim, Dae-Hee Lee, Sang Cheul Oh. Docosahexaenoic acid enhances Oxaliplatin-induced autophagy via ER stress/SESN2 pathway in colorectal cancer.Cancers (Basel). 2019 Jul 14;11(7).(교신저자) 78. 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1. Lee, D. H., Kim, S. H., Lee, S. Y., Choi, C., Jun, W. J., Shin, D. H., Cho, H. Y., and Hong, B. S. Extract from Gelidium amansii Having Gut Immunity Activity and Method Therefore. Korea patent pending, the application number: 10-2003-0070671, Oct 10, 2003 2. Lee, D.H., Ha, N. N., Bu, Jung, J. H., Y. M., Kim, M. Y., and Kim, H. C. Composition comprising oleic acid having neuronal cell-protecting activity for preventing and treating the degenerative brain disease. Korea patent pending, the application number: 10-2005-0076324, Sept 12 3. 오상철, 오상욱, 이대희. 복수의의료영상에서의동일병변영역추적장치및방법 (2017-0047267) 4. 오상철, 오상욱, 이대희. 환자맞춤형진단보조정보제공시스템, 장치및방법 (2017-008092) 5. 이대희, 오상철, 조민지 , Romo1 억제제를포함하는 TRAIL에대한감수성증진용조성물 (10-2017-012187) 6. 이대희, 오상철, 박성혜, 항암제내성진단용바이오마커및이의용도 (10-2017-0126168) 7. 이대희, 오상철, 조민지, RUNX3 단백질또는이를코딩하는 RUNX3 유전자를포함하는암예방또는치료용약학조성물 (2017-0162891) 8. 이대희, 오상철, 유상권, 박성혜, 해삼추출물또는이의분획물, 및 TRAIL 단백질을포함하는암예방또는치료용조성물 (2018-0003262) 9. 이대희, 오상철, 유상권, 김정림, 박성혜, 청각추출물또는이의분획물, 및 TRAIL 단백질을포함하는암예방또는치료용조성물 (2018-0003261) 10. 이대희, 오상철, 다이알릴다이설파이드및 TRAIL 단백질을포함하는암예방또는치료용조성물 (2018-0041452) 11. 이대희, 오상철, 카나비디올추출물및트레일을함유하는대장암예방또는치료용약학조성물 (2018-0018830) 12. 이대희, 오상철, 칸나비디올추출물을함유하는대장암예방또는치료용약학조성물 (2018-0018829)